Key Functions:

GEN-TEC NUTRITION'S PSYCHED 2.0 is a unique pre-workout formula designed for individuals engaging in high intensity training with goals of increased performance and lean muscle mass. The synergistic blend of ingredients in PSYCHED 2.0 have been combined to assist focus/vigilance and energy levels while supporting an enhanced muscular pump during weight training. PSYCHED 2.0 is fortified with C and B group vitamins to support adrenal function and reduce post exercise fatigue. 

SUGGESTED USE: Mix 5g (1 heaped tsp) of PSYCHED 2.0 in 250mL of water and consume 15 minutes before intensive exercise. Store in a cool, dry, dark place.

INGREDIENTS: Creatine monohydrate (Creapure), L-arginine AKG, L-citrulline DL malate, flavours, acidity regulators (citric acid, malic acid), L-tyrosine, caffeine, sweetener (sucralose), vitamins (C, B3, B12, B5, B2, B6, B1), anti-caking agent (silicon dioxide), natural colour (copper chlorophyllin). Contains caffeine.

May contain traces of milk, soybeans, cereals containing gluten, tree nuts, egg, sesame seeds and their products.

DISCLAIMER: Not suitable for children under the age of 15 or pregnant women, should only be used under medical or dietary supervision. This food is not a sole source of nutrition and should be used in conjunction with a sensible exercise and nutrition program.

Packed in Australia from imported and local ingredients.


By Dane Ivicevic: BSc, GradDip, GradCert, Dip, TAE
Gen-Tec Resident Biochemist

Multi-ingredient pre-workout supplement
Pre-workout supplementation is one of the most commonly practiced protocols used by exercising individuals, often before correct nutrition and nutrient timing around training.
This has led to the rise of numerous products all with the goal of giving the consumer an energy hit. However, the short fall to this is often an overshoot in stimulation or the lack
of co-nutrients to support a mental and physical enhancement without significant side effects or a crash. The use of caffeine is the leading ingredient in most pre-workout
supplements, however caffeine use can be a delicate balance between stimulatory enhancement and an array of unnerving side effects. Therefore, a multi-ingredient
pre-workout supplement is needed that will not only enhance but also support an ergogenic potential.

An excellent example of a multi-ingredient pre-workout supplement was evident in the small randomised, placebo controlled, double blind trial involving the use of a multi-ingredient pre-workout supplement which contained caffeine, tyrosine, creatine and B vitamins specifically (1). The outcomes of the protocol lead to statistically significant improvements in performance and body composition over 28 days. What was also examined and reported in this trial was that the use of this supplement mix resulted in no reported side effects on; liver, heart rate and blood pressure during the 28-day period (1). The efficacy and safety of this model of pre-workout supplementation has also been supported by various other papers examining multi-ingredient supplementation during exercise (2, 3).

Pump and anti-fatigue
The incorporation of arginine and citrulline malate (CM) essentially leads to a greater endogenous (internal) increase in nitric oxide production, which in turn significantly increases vasodilation and circulation. Small randomised controlled trials have reported that CM either improves recovery from repeated anaerobic bouts or enhanced performance by promoting aerobic energy production and muscle oxygenation (4-7).

Mental focus, performance and vigilance
During periods of high physical exertion and prolonged exercise, mental focus can take a significant hit, especially when hard training is involved. The adverse effects of this
can be overcome by supplementing tyrosine and caffeine. Tyrosine is an amino acid which manufactures neurotransmitters like dopamine, norepinephrine and epinephrine (8). Tyrosine has been observed to increase performance on stress-sensitive attention
tasks which would otherwise lead to a decline in cognitive (mental ability) capacity (9-11). During acute periods of stress there is a heightened use of tyrosine-dependent
neurotransmitters which is a contributing factor to the reduction in motivation, attention and working memory. Therefore, consuming tyrosine can increase “brain power” under
times of moderate-heavy stress (9). Caffeine not only combats fatigue but it aids in the release of endorphins which reduce the perception of pain during exercise (12). In addition, like tyrosine, it stimulates the production of neurotransmitters like dopamine and norepinephrine, which improves alertness and vigilance during periods of fatigue and sleep deprivation (13, 14).

Anti-fatigue and performance support
Water soluble vitamins like B and C are heavily involved as co-enzymes in energy dependent pathways which is stressed to a great degree in those who exercise
compared to those who don’t. The use of nutrients such as carbohydrates and amino acids requires sufficient levels of B vitamins like B6 and folate to assist in the creation of
energy to support exercising demands (15, 16). It is established that exercise likely modifies the metabolic need and requirements of B vitamins which although may not
adversely impact performance, it can impact recovery and long term health status (15). Specifically, the metabolism of amino acids like methionine and creatine and the
depletion of B vitamins during metabolism give rise to a product called homocysteine which when chronically high, is a potential marker for disease, inflammation and fatigue
(17). While its very unlikely that exercise increases the risk of disease though homocysteine levels, it does appear to influence fatigue and recovery specifically, which appear
to be highly individual in regards to the significance and impact it has. Those who supplement these water-soluble vitamins appear to support adrenal function during
times of heightened cortisol production, maintain higher blood level of B vitamins during and post exercise as well as experience lower homocysteine levels in the blood post exercise (16, 17).

Moreover, the addition of creatine works not only to increase training performance by acting as a muscle fuel during high intensity exercise, but it also works with B vitamins
to reduce homocysteine levels in the blood. This is turn may alleviate fatigue and enhance recovery (18). By using a more pure and clean source of creatine, an athlete
receives more active creatine per gram and significantly less contaminants and creatinine than other competing creatine products which surprisingly is more common than it should be (19, 20).

1. Kendall KL, Moon JR, Fairman CM, Spradley BD, Tai C-Y, Falcone PH, et al. Ingesting a preworkout supplement containing
caffeine, creatine, -alanine, amino acids, and B vitamins for 28 days is both safe and efficacious in recreationally active men.
Nutrition Research. 2014;34(5):442-9.
2. Jagim AR, Jones MT, Wright GA, St. Antoine C, Kovacs A, Oliver JM. The acute effects of multi-ingredient pre-workout ingestion
on strength performance, lower body power, and anaerobic capacity. Journal of the International Society of Sports Nutrition.
3. Smith AE, Fukuda DH, Kendall KL, Stout JR. The effects of a pre-workout supplement containing caffeine, creatine, and amino
acids during three weeks of high-intensity exercise on aerobic and anaerobic performance. Journal of the International Society of
Sports Nutrition. 2010;7(1):10.
4. Wax B, Kavazis AN, Weldon K, Sperlak J. Effects of Supplemental Citrulline Malate Ingestion During Repeated Bouts of
Lower-body Exercise in Advanced Weight Lifters. Journal of Strength & Conditioning Research. 2015.
5. Bailey SJ, Blackwell JR, Lord T, Vanhatalo A, Winyard PG, Jones AM. L-Citrulline supplementation improves O2 uptake kinetics
and high-intensity exercise performance in humans. Journal of Applied Physiology. 2015;119(4):385.
6. Bendahan D, Mattei JP, Ghattas B, Confort-Gouny S, Le Guern ME, Cozzone PJ. Citrulline/malate promotes aerobic energy
production in human exercising muscle. British Journal of Sports Medicine. 2002;36(4):282.
7. Cunniffe B, Papageorge M, O'Brien B, Grimble GK, Davies NA, Cardinale M. The Acute Effects of Citrulline-Malate Supplementation
on High Intensity Cycling Performance and Muscle Oxygenation. 2002.
8. O'Brien C, Mahoney C, Tharion WJ, Sils IV, Castellani JW. Dietary tyrosine benefits cognitive and psychomotor performance
during body cooling. Physiology & Behavior. 2007;90(2–3):301-7.
9. Mahoney CR, Castellani J, Kramer FM, Young A, Lieberman HR. Tyrosine supplementation mitigates working memory decrements
during cold exposure. Physiology & Behavior. 2007;92(4):575-82.
10. Neri DF, Wiegmann D, Stanny RR, Shappell SA, McCardie A, McKay DL. The effects of tyrosine on cognitive performance during
extended wakefulness. Aviation, space, and environmental medicine. 1995;66(4):313-9.
11. Bjork JM, Grant SJ, Chen G, Hommer DW. Dietary Tyrosine/Phenylalanine Depletion Effects on Behavioral and Brain Signatures
of Human Motivational Processing. Neuropsychopharmacology. 2014;39(3):595-604.
12. Sökmen B, Armstrong LE, Kraemer WJ, Casa DJ, Dias JC, Judelson DA, et al. CAFFEINE USE IN SPORTS: CONSIDERATIONS FOR
THE ATHLETE. Journal of Strength and Conditioning Research. 2008;22(3):978-86.
13. Goldstein ER, Ziegenfuss T, Kalman D, Kreider R, Campbell B, Wilborn C, et al. International society of sports nutrition position
stand: caffeine and performance. Journal of the International Society of Sports Nutrition. 2010;7(1):5.
14. Lieberman HR, Tharion WJ, Shukitt-Hale B, Speckman KL, Tulley R. Effects of caffeine, sleep loss, and stress on cognitive
performance and mood during U.S. Navy SEAL training. Sea-Air-Land. Psychopharmacology. 2002;164(3):250-61.
15. Manore MM. Effect of physical activity on thiamine, riboflavin, and vitamin B-6 requirements. Am J Clin Nutr. 2000;72(2
16. Kim Y-N, Hwang JH, Cho Y-O. The effects of exercise training and acute exercise duration on plasma folate and vitamin B(12).
Nutrition Research and Practice. 2016;10(2):161-6.
17. Konig D, Bisse E, Deibert P, Muller HM, Wieland H, Berg A. Influence of training volume and acute physical exercise on the
homocysteine levels in endurance-trained men: interactions with plasma folate and vitamin B12. Annals of nutrition & metabolism.
18. Persky AM, Brazeau GA. Clinical pharmacology of the dietary supplement creatine monohydrate. Pharmacological Reviews.
19. Moret S, Prevarin A, Tubaro F. Levels of creatine, organic contaminants and heavy metals in creatine dietary supplements. Food
Chemistry. 2011;126(3):1232-8.
20. Jäger R, Purpura M, Shao A, Inoue T, Kreider R. Analysis of the efficacy, safety, and regulatory status of novel forms of creatine.
Amino Acids. 2011;40(5):1369-83.
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